Scientist High Content Screening- Cellular and Tissue Genomics

Profile

The Department of Cellular and Tissue Genomics within Genentech Research and Early Development is seeking a highly talented, creative and driven Scientist to generate and utilize high content perturbation maps for biological and drug discovery and to develop novel technologies for high information content screening.

This individual will lead an independent research group whose mission is to develop and apply scalable tools for screens for complex biological phenotypes. The experimental and computational toolbox developed should create a path to comprehensively characterize cell and tissue circuits at the single cell level, and to better understand the function of genetic variants in complex diseases.

The scope of the screening activities will span biological disciplines, including immunology, molecular oncology, cancer immunology, angiogenesis, neurobiology and regenerative medicine. The scientists will play a key role in leading and contributing to teams in disease areas of focus. They will apply these tools to perform cutting edge screens to identify novel therapeutic targets and next-generation biomarkers to enable precision medicine therapies for patients.

Responsibilities

Pursue scalable tools enabling pooled genome-wide and combinatorial high information content single-cell screens in biologically relevant models (e.g. patient cells, in vivo, organoids)

Develop new screening modalities by combining an expanding perturbation toolkit (e.g. gene editing, epigenome editing, base editing, overexpression) with cutting-edge information-rich single-cell read-outs (e.g. RNA, chromatin, protein, morphology, lineage fate)

Collaborate with disease experts across the different therapeutic areas to design screens tailored to biological discovery capturing physiology of disease

Work together with machine learning teams to develop and apply models to describe molecular circuitry and identify new biomarkers and therapeutic targets

Analyze available datasets or profile clinical trial samples to inform screen design for biomarker and drug discovery

Mentor colleagues to enable their scientific potential

Publish in high quality scientific journals and present externally though presentations at key internal and external meetings, advisory boards, and conferences

Qualifications

Ph.D. with relevant postdoctoral experience gaining both experimental and computational expertise in genetics and systems biology using single-cell RNA-seq (scRNA-seq) methods

Strong publication record of impactful discoveries that reveal novel biological pathways and/or advanced technologies to enable biological discovery

Experience with performing large scale single cell screens ( e.g.

Perturb-Seq) collecting multimodal single-cell readouts (chromatin, RNA, protein, optical) in various settings including in vivo

, ex vivo

, and cell line systems

Experience with inventing and deploying new single-cell screening methods ( e.g.

split-pool, ASAP-Seq, SHARE-Seq)

Experience applying diverse CRISPR technologies (CRISPR gene editing, activation, repression) in vivo

, ex vivo

, and in cell lines

Proficient in computational biology including high throughput omics (including scRNA-seq), visualization, and interpretation

Excellent interpersonal skills with demonstrated ability to work within a team comprised of diverse expertise

Excellent mentoring skills across all levels

Excellent oral and written presentation skills

Who We Are

Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.

Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.

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Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page

Company info

Genentech, Inc.
Website : http://www.gene.com