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Sr Scientist Molecular Genomics Early Target Discovery

Location
San Diego, CA

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Job Description:
By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that I agree with Takeda’s Privacy Notice
, Privacy Policy
and Terms of Use
Job Description
OBJECTIVES: 
The Senior Scientist, Molecular Genomics within Early Target Discovery is responsible for functional characterization of SNPs and genetic variants associated with diseases aiding target identification and validation (TIDVAL) in Takeda’s Research in support of initiating drug discovery programs. Utilizes cutting edge molecular and high throughput technologies for functional characterization of disease associated SNPs, genes, miRNAs, microproteins, splicing, or transposons. Studies mechanistic basis of causal and protective variants association to diseases.
ACCOUNTABILITIES: 
Employs a multi-disciplinary approach, combining genome engineering, pooled genetic screens, bioinformatics, electrophysiology, and imaging, to dissect the inner workings of the human genome and pathogenic mechanisms 
Designs and implements functional characterization strategies for disease associated SNPs/variants identified from patient genetics
Responsible for high throughput molecular biology work streams in TIDVAL
Identify opportunities to collaborate with partners (academic, biotech, and CRO) to enhance in-house capabilities.
Proposes, designs, and executes in vivo and in vitro studies to support Takeda programs.
Works and communicates effectively with colleagues of differing backgrounds and experience levels
Provides analysis and interpretation of data; writes study reports and presents data effectively in all settings and with participants of all levels of the organization.
Keeps up to date with appropriate literature and scientific developments and uses knowledge to propose new programs or support current programs
Represent own research findings to leadership and project teams.
Professionally represents the organization in collaborations, partnership discussions, and external conferences.
EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS: 
Ph.D. in molecular biology or molecular genetics or bioengineering or related discipline with 4 years of combined post-doctoral, biotech/pharma industry experience and publication record OR
MS in Life Science with 14 years of relevant experience and publication record.
Extensive hands-on experience in some of the techniques with human biopsies: HT molecular biology, recombinant expression, RNAseq, whole genome/exome sequencing, HT genome-wide CRISPR editing, mRNA splicing, modulation of miRNA and microprotein expression, IHC, 2D-DIGE, etc.
Track record of working on complex problems, and ability to integrate data from multiple disciplines
Strong interpersonal, collaboration skills to work in a team-oriented, fast-paced, matrix environment, and the ability to work through conflicts
Highly motivated and flexible with a positive can-do attitude
Ability to provide novel creative solutions to challenging problems
Desire to learn and tackle new challenges and initiatives
LICENSES/CERTIFICATIONS:
None required  
PHYSICAL DEMANDS: 
Working in cold room (4°C)
Able to lift or move up to 10 pounds on a regular basis during daily work.
Exposure to hazardous/toxic/dangerous chemicals
TRAVEL REQUIREMENTS:
Less than or equal to 5% travel, consisting of one to two relevant scientific meetings and/or trips to meet with collaborators and CROs
WHAT TAKEDA CAN OFFER YOU:
401(k) with company match and Annual Retirement Contribution Plan
Tuition reimbursement
Company match of charitable contributions
Health & Wellness programs including onsite flu shots and health screenings
Generous time off for vacation and the option to purchase additional vacation days
Community Outreach Programs
Empowering Our People to Shine
Learn more at takedajobs.com
No Phone Calls or Recruiters Please.
#LI-KL1
Locations
San Diego, CA
Worker Type
Employee
Worker Sub-Type
Regular
Time Type
Full time
Apply Now
By clicking the “Apply” button, I understand that my employment application process with Takeda will commence
and that I agree with
Takeda’s
Privacy Notice
, Privacy Policy and Terms of Use .
Job Description
OBJECTIVES:  The Senior Scientist, Molecular Genomics within Early Target Discovery is responsible for functional characterization of SNPs and genetic variants associated with diseases aiding target identification and validation (TIDVAL) in Takeda’s Research in support of initiating drug discovery programs. Utilizes cutting edge molecular and high throughput technologies for functional characterization of disease associated SNPs, genes, miRNAs, microproteins, splicing, or transposons. Studies mechanistic basis of causal and protective variants association to diseases. ACCOUNTABILITIES:  Employs a multi-disciplinary approach, combining genome engineering, pooled genetic screens, bioinformatics, electrophysiology, and imaging, to dissect the inner workings of the human genome and pathogenic mechanisms 
Designs and implements functional characterization strategies for disease associated SNPs/variants identified from patient genetics
Responsible for high throughput molecular biology work streams in TIDVAL
Identify opportunities to collaborate with partners (academic, biotech, and CRO) to enhance in-house capabilities.
Proposes, designs, and executes in vivo and in vitro studies to support Takeda programs.
Works and communicates effectively with colleagues of differing backgrounds and experience levels
Provides analysis and interpretation of data; writes study reports and presents data effectively in all settings and with participants of all levels of the organization.
Keeps up to date with appropriate literature and scientific developments and uses knowledge to propose new programs or support current programs
Represent own research findings to leadership and project teams.
Professionally represents the organization in collaborations, partnership discussions, and external conferences.
EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS:  Ph.D. in molecular biology or molecular genetics or bioengineering or related discipline with 4 years of combined post-doctoral, biotech/pharma industry experience and publication record OR
MS in Life Science with 14 years of relevant experience and publication record.
Extensive hands-on experience in some of the techniques with human biopsies: HT molecular biology, recombinant expression, RNAseq, whole genome/exome sequencing, HT genome-wide CRISPR editing, mRNA splicing, modulation of miRNA and microprotein expression, IHC, 2D-DIGE, etc.
Track record of working on complex problems, and ability to integrate data from multiple disciplines
Strong interpersonal, collaboration skills to work in a team-oriented, fast-paced, matrix environment, and the ability to work through conflicts
Highly motivated and flexible with a positive can-do attitude
Ability to provide novel creative solutions to challenging problems
Desire to learn and tackle new challenges and initiatives
LICENSES/CERTIFICATIONS: None required  
PHYSICAL DEMANDS:  Working in cold room (4°C)
Able to lift or move up to 10 pounds on a regular basis during daily work.
Exposure to hazardous/toxic/dangerous chemicals
TRAVEL REQUIREMENTS: Less than or equal to 5% travel, consisting of one to two relevant scientific meetings and/or trips to meet with collaborators and CROs
WHAT TAKEDA CAN OFFER YOU:
401(k) with company match and Annual Retirement Contribution Plan
Tuition reimbursement
Company match of charitable contributions
Health & Wellness programs including onsite flu shots and health screenings
Generous time off for vacation and the option to purchase additional vacation days
Community Outreach Programs
Empowering Our People to Shine
Learn more at
takedajobs.com
No Phone Calls or Recruiters Please.
#LI-KL1
Locations
San Diego, CA
Worker Type
Employee
Worker Sub-Type
Regular
Time Type
Full time >
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