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Senior Scientist Computational Genomics Boston

Company name
Merck & Co., Inc

Boston, MA

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Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its

legacy for over a century

. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is dedicated to turning causal human genetics and biology into new, differentiated disease modifying therapies to improve the lives of patients across auto-immune, cardio-metabolic and neurodegenerative disease. To fulfill this mission the Quantitative Target Sciences (QTS) group in the Human Genetics and Pharmacogenomics Department (GpGx) is searching for a highly collaborative and inquisitive scientist to join an inter-disciplinary team to transform human disease genetic discoveries into testable therapeutic hypotheses. We are looking for computational genomicist or bioinformatician with extensive experience analyzing and interpreting human genomic data and its integration with human genetic complex disease and quantitative trait association data. The successful candidate will participate in the statistical design and analysis of genomic experiments including capture Hi-C, CRISPR screens, bulk RNA-seq, single-cell RNA-seq, ATAC-seq and others. The candidate should have a solid foundation in statistics and computational biology, a strong work ethic, the ability to work independently and an openness to work on highly collaborative, matrixed teams. The candidate will develop and leverage academic collaborations, public-private partnerships and publically available data for the purpose of target identification and validation. This position affords the successful candidate an amazing opportunity to collaborate with scientists from across the organization including biostatistics, epidemiology, chemical-biology, functional genomics and genetics. This computational genomics position within QTS provides a unique opportunity to harness the power and information from human genetics and genomics to support the development of novel therapeutics.



Ph.D., minimum of 2 years post degree experience (industry preferred) desired but all experience levels will be considered


Knowledge of experimental design

Management and analysis of large genomics studies (e.g. GTEx, BLUEPRINT, ENCODE)

Knowledge of NGS & genomics statistical analyses and software (e.g. differential expression, eQTL, capture Hi-C, ATAC-seq, MPRA, etc.)

Statistical programming skills (R/MATLAB)

Programming/Scripting skills (Python/Perl/Shell/etc.)

Knowledge of modern human genetics (GWAS, RVAS, etc.)

Knowledge of network/graph theory and application to genomics

Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life.

If you need an accommodation for the application process please email us at [email protected]

Search Firm Representatives Please Read Carefully:

Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck. No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.

For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster

EEOC GINA Supplement



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Company info

Merck & Co., Inc
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Company Profile
Merck has a long and rich history of working to improve people's health and well-being. Through the years, our researchers have helped to find new ways to treat and prevent illness - from the discovery of vitamin B1, to the first measles vaccine, to cold remedies and antacids, to the first statins to treat high cholesterol. Our scientists also have helped develop many products to improve animal health, including vaccines and antibiotics. /images/merck-history-timeline-screen.jpgWhile we are proud of our past, we are enthusiastic about the future of this new company and we are excited to help create a healthier, brighter future for people around the world.

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