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Senior Associate Scientist Protein Expression

Location
Spring House, PA

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Senior Associate Scientist, Protein Expression','1072180510','!*!Janssen Research
and Development, L.L.C., a member of Johnson and Johnson's Family of Companies,
is recruiting for a Senior Associate Scientist, Protein Expression to be in
Spring House, PA. 

 

At
the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters
most is helping people live full and healthy lives. We focus on treating,
curing and preventing some of the most devastating and complex diseases of our
time. And we pursue the most promising science, wherever it might be found.

 

Janssen
Research & Development, LLC discovers and develops innovative medical
solutions to address important unmet medical needs in oncology, immunology,
neuroscience, infectious diseases and vaccines, and cardiovascular and
metabolic diseases.  Please visit ****more information. 

 

We
are Janssen. Our mission drives us. Our patients inspire us. We collaborate
with the world for the health of everyone in it. Thriving on a diverse company
culture, celebrating the uniqueness of our employees and committed to
inclusion.  Proud to be an equal opportunity employer.

 

The
new Lead Discovery team is a critical part of the Discovery Sciences
organization in Janssen R&D and is committed to the delivery of high
quality chemical leads needed for the generation of small molecule clinical
compounds in all five Janssen Therapeutic Area discovery teams.  This
mission requires deep scientific expertise in a number of disciplines including
chemistry, cellular pharmacology, screening and protein science coupled with an
ability to work collaboratively with internal and external partners.

 

The
Protein Science department within Lead Discovery is responsible for the
delivery of proteins to enable assay development, HTS, pharmacological
profiling and structural biology (X-ray crystallography and NMR).  The
Protein Science Team collaborates closely with Janssen Therapeutic Areas and
functional teams and with external collaborators in academia and
industry.  We seek individuals with a strong ability to connect key stake
holders for the delivery of goals and objectives, fostering an environment of
collaboration, collegiality and positive communication, and who show superior
performance in the context of a multidisciplinary, geographically disperse
team.  The Senior Associate Scientist, Protein Expression will:

Participate in the design and implementation of protein expression
strategies that provide active proteins for use in assays and structural
biologyActively
contribute in protein expression activities including expression optimization
& screening from bench-scale to scale-up utilizing bacterial (E.coli), insect (BEVS),
and mammalian expression systemsAnalyze, interpret, summarize and report experimental dataDevelop innovative approaches to protein expression including
evaluation of new technologiesRemain
current with applicable internal/external scientific literature and apply new
information to successfully complete work assignments. Exhibit
great work ethic and maintain a high level of productivity in the laboratoryCollaborate across multiple therapeutic and functional areas in
the US, Europe and AsiaExhibit strong team spirit: capable of working in a team-based
environment spanning multiple disciplines and
collaborating with scientists and associates in a fast-paced, energetic
environmentBe independent and self-motivated, with a strong sense of urgency
and abilityAttend in-house seminars and external scientific meetings as
appropriate

















','!*!B.S./B.A with a minimum
of 7 years of work experience in recombinant protein production OR a Master’s
degree with a minimum of 4 years of work experience in recombinant protein
production is requiredExpertise in the recombinant expression of proteins in insect cell
and mammalian cell lines is requiredExperience in the recombinant expression of proteins in E. coli
bacteria and cell-free systems is preferredExpertise in protein
expression analysis using techniques such as electrophoresis, Western Blot,
flow cytometry, FSEC, protein pull-downs is requiredExperience
working with automated laboratory workflows and instrumentation is
preferredExperience in the analysis of proteins using different
chromatographic techniques such as affinity, ion exchange, hydrophobic
interaction, size exclusion is preferredIndustry experience is preferredExpertise in protein construct design is preferredExperience working with external collaborators in industry or
academia is preferred















','North America-United States-Pennsylvania-Spring House','','Janssen Research & Development, LLC. (6084)','','','Yes, 10 % of the Time','R&D','Senior Associate Scientist, Protein Expression

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