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Job Details

Senior Scientific Researcher Tumor Microenvironment Cellular and Tissue Genomics

Company name
Genentech, Inc.

South San Francisco, CA, United States

Employment Type

Biotech, Sciences, Research, Post Doc

Posted on
Oct 27, 2020

Valid Through
Feb 09, 2021

Apply for this job


The Cellular and Tissue Genomics Department is seeking a highly talented and motivated Senior Scientific Researcher to dissect cellular and tissue circuits regulating the tumor microenvironment. The successful candidate will implement and apply cellular immunology, single cell sequencing (cell suspension and spatially-resolved), gene editing, and mouse models to understand the molecular mechanisms underlying the complex tumor ecosystem. We are seeking an enthusiastic individual who is eager to make intellectual as well as technical contributions to our team by developing and deploying new single cell genomics tools and applying cutting edge screens to identify novel preclinical therapeutic targets and biomarkers.


Advance a combination of sophisticated pooled genetic screens to connect the genetic and molecular basis of disease

Develop in vivo

and ex vivo

systems for single and combinatorial genetic perturbations

Engineer new spatial genomics technologies

Pursue scalable tools enabling genome-wide or combinatorial high information content screens

Collaborate with AI and Bioinformatics groups as a team member for analysis and development of novel models to understand genetic circuits in health and disease.

Independently design, execute, and present studies to various forums within the department and across the wider Research organization.


Ph.D. with 2 years of relevant postdoctoral experience gaining expertise in molecular biology, immunology or immuno-oncology, scRNA-seq, spatial genomics, and high information content screens

Documented record of professional achievement demonstrated by high impact publications

Mastery of primary cell isolation, cell culture, and flow cytometry with a strong background in innate or adaptive immunity and cancer biology is preferred

Experience using CRISPR technology to study gene function through applications in vivo

, ex vivo

, and in cell lines

Excellent interpersonal skills with demonstrated ability to work within a team comprised of diverse expertise

Excellent oral and written presentation skills, creative problem-solving flexibility, and the ability to integrate detailed analysis into larger disease-oriented context is required.



Who We Are

Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.

Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.

The next step is yours. To apply today, click on the Apply for this job button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page

Company info

Genentech, Inc.
Website :

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