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Postdoctoral Research Fellow Structural Biology Lupardus lab Genentech Research

San Francisco, CA

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Genentech: Postdoctoral Research Fellow, Structural Biology, Lupardus lab, Genentech Research
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Postdoctoral Research Fellow, Structural Biology, Lupardus lab, Genentech Research
South San Francisco
California, United States of America
Job ID: 2953408056
The Position
A position is available for a postdoctoral fellow with expertise in protein biochemistry and structural biology methods to join the Lupardus group in the Department of Structural Biology at **MEMBERS ONLY**SIGN UP NOW***. My lab has an active research program around the structure and function of receptor-coupled kinase signaling cascades involved in innate and adaptive immunity, with the goal of both deciphering the activation mechanisms as well as to aid in therapeutic design. The successful candidate will be responsible for all aspects of their projects, including expression and purification of proteins and complexes, crystallization, data collection, structure determination and analysis of resulting structures. Our department has state of the art facilities for both X-ray crystallography and cryo-Electron Microscopy, and the candidate will ideally utilize both methods for projects during their tenure. He/she will also have a strong desire to take part in vitro assay development, protein engineering, and/or biophysical characterization to facilitate understanding of these structures.
Relevant papers: - Ferrao R, Lupardus PJ. (2017) The Janus Kinase (JAK) FERM and SH2 Domains: Bringing Specificity to JAK-Receptor Interactions. Front Endocrinol 8, 71. - Ferrao R, Wallweber HJA, Ho H, Tam C, Franke Y, Lupardus PJ. (2016) The structural basis for Type II cytokine receptor recognition by JAK1. Structure 24, 897-905. - Lupardus PJ, Ultsch M, Wallweber H, Bir Kohli P, Johnson A, Eigenbrot C. (2014) The structure of the TYK2 pseudokinase/kinase protein reveals a mechanism for JAK autoinhibition. Proc Nat Acad Sci 111, 8025-30. - Wallweber HJA, Tam C, Franke Y, Starovasnik MA, Lupardus PJ. (2014) Structural basis of IFN? receptor recognition by TYK2. Nat Struct Mol Biol 21, 443-8. - Lupardus PJ, Skiniotis G, Rice AJ, Thomas C, Fischer S, Walz T, and Garcia KC. (2011) Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6R? cytokine receptor complex, and the receptor-Jak1 holocomplex. Structure 19, 45-55. For more information on Patrick Lupardus lab, please visit: ****Information about the postdoctoral program at Genentech can be found at: ****The successful candidate will be a motivated individual capable of operating independently and collaborating effectively in Genentech’s highly collaborative environment. Candidates must have a Ph.D. in structural biology, biophysics, biochemistry or related discipline. A strong background in biochemistry and protein crystallography and/or cryo-EM is required, demonstrated by successful purification, characterization and crystallization of challenging proteins and evidenced by a first author paper published or accepted in a peer-reviewed journal. Expertise in protein engineering, biophysical techniques, and/or in vitro enzymatic assays is a plus.
Who We Are
A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.
The next step is yours. To apply today, click on the Apply online button.
Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our .
At Genentech, we share salary ranges with applicants during the recruiting process, if requested. Third party salary estimates may not be accurate or up-to-date.
Job Facts
Job Function
South San Francisco
California, United States of America
Full time
Job type
Temporary (Fixed Term)

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