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Postdoctoral Fellow

Company name
Pfizer Inc

Groton, CT

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Postdoctoral Fellow




Job #667880385

We are seeking a highly qualified and energetic PhD scientist to join us in the Structural and Molecular Sciences (SMS) department at the Pfizer Groton, Connecticut campus as a postdoctoral researcher focused on elucidating the three dimensional structures of integral membrane protein complexes that serve as important therapeutic targets. The successful candidate will be trained in the state-of-the-art science of membrane protein structural biology, be exposed to drug discovery and development process, and will learn the application of structural data for drug design. At SMS, we have extensive in-house experience and resources supporting membrane protein expression, purification, crystallization, and structure determination by both X-ray crystallography and cryo-EM. Presently, Pfizer scientists have regular access to all the major X-ray synchrotron beam lines in the world and well-established in-house cryo-EM facilities. Ideal candidates should have extensive experience in molecular biology, protein expression, purification, and characterization.

Role Responsibilities

Design and optimize membrane protein constructs for functional expression and stabilization, 0-3 years of experience

Purification of membrane proteins and soluble partners/transducers for complex assembly and structural determinations.

Functional characterization of the membrane protein complexes by biophysical/biochemical studies.

Protein crystallization and data collection. Cryo-EM sample preparation and data collection. Data analysis and structure determination. Structure analysis to understand structure-function relationship. Design and characterize site-specific variants to evaluate structural hypotheses.

Interface with scientists across lines/disciplines and show strong initiative in developing ideas to assist in the design of exploratory experiments.

Collect up-to-date information and keep abreast of the relevant literature, data acquisition and analysis, manuscript preparation, presentation of study results in oral and poster formats.


Ph.D. in structural biology or biochemistry with extensive knowledge in molecular biology, protein biochemistry and wet lab protein structural biology skills.

Previous experience with protein construct design, expression and purification is required.

Previous experience with membrane protein desirable.

Previous working experience with X-ray crystallography or cryo-EM technology is a plus.

Demonstrated track record of publication in peer-reviewed scientific journals.

Excellent communication skills and ability to work independently are essential.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

Updated 05/16/2018

Company info

Pfizer Inc
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Company Profile
Good health is vital to all of us, and finding sustainable solutions to the most pressing health care challenges of our world cannot wait. That's why we at Pfizer are committed to applying science and our global resources to improve health and well-being at every stage of life. We strive to provide access to safe, effective and affordable medicines and related health care services to the people who need them.

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