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Job Details

Principal Scientist Translational Bioinformatics Computational Proteomics

Company name
Bristol-Myers Squibb Company

Cambridge, MA, United States

Employment Type

Biotech, Sciences, Scientist

Posted on
Nov 23, 2020

Valid Through
Mar 08, 2021

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At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

We are seeking a highly motivated computational scientist with academic and/or industry experience to join our Computational Genomics team in the Translational Bioinformatics group in Cambridge, MA. The successful candidate will lead the Computational Proteomics group which is responsible for exploring innovative research methods to analyze and interpret proteomics and protegenomics data sets, , establishing best practices and robust data analysis workflows, and providing subject matter expertise to project teams and other stakeholders across the company. In this key role the individual will actively interface with the Discovery & Translational Proteomics team in Cambridge, Discovery and Translational research teams working on various drug development programs, as well as the broader bioinformatics teams within the Integrative & Predictive Sciences (IPS) organization.


Build and lead an industry leading Computational Proteomics group

Set scientific strategy and objectives in collaboration with stakeholders

Advocate, adopt and influence overall industry best practices associated with computational proteomics & proteogenomics

Ensure adherence to best practices within the group

Interface with and leverage wider computational genomics capabilities within the IPS organization

Effectively communicate best practices to key stakeholders and provide a platform that streamlines the implementation across all BMS sites

Develop, optimize, and monitor innovative use of Proteomics applications from Discovery through Translation to advance BMS pipeline projects to achieve our mission of helping patients with unmet needs


Ph.D. with 3-5 years, or Masters with 5-10 years of relevant (industry or academia) experience is required. Education should be in the fields of Computer Science, Computational Biology, Bioinformatics, Molecular Biology, Biochemistry, or related disciplines

Ability to lead a team of highly skilled scientists in a matrixed environment

Deep experience in Proteomics data structure of latest platforms (DIA, DDA, label free, targeted, chemical proteomics, TMT, SILAC) is required

Profficency with utilization of outputs from proteomics software packages such as Maxquant, PEAKS, Spectronaut, Bioworks and other is required

Proven experience in developing, optimizing and maintaining proteomics data processing pipelines

Deep familiarity with Design of Experiment and associated statistical methods is necessary

Proven experience in Cloud computing system (AWS or Google Cloud) and databases (SQL, PostgreSQL BigQuery). Experience in Seven Bridges, Domino and R shiny app development will be a plus

Experience in mining public protein -omics data repositories (e.g. CPTAC, MassIVE, PRIDE, PeptideAtlas, ProteinAtlas, ProteomeXchange Phosphosite, BioGrid, IntAct, TCGA, cBioportal, DepMap, COSMIC, GeneBank, ProteinAtlas, CMAP)

Proficiency integrating and analyzing high-dimensional data, omics data sets (Proteomics, RNAseq and other NGS data) to deliver insights and hypothesis: e.g. multivariate, casual interference, Bayesian statistics or machine learning. Working knowledge of functional genomics and network biology is a plus

Experience in NGS data processing pipelines and Proteogenomics is highly desirable

Extensive experience in programming, scripting, querying and statistical analysis languages such as R, Python, Perl, Bash, Java is a must.

Proven expertise in different aspects of NGS and proteomics is required. Expertise in proteogenomics is desirable.

Excellent communication and collaboration skills are essential in order to enable working across Discovery & Translational organizations

Proven ability to publish research is required

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Company: Bristol Myers Squibb

Req Number: R1532184-en-us

Updated: 2020-11-24 00:28:10.553 UTC

Location: Cambridge,Massachusetts

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.

Company info

Bristol-Myers Squibb Company
Website :

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