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Job Details

Associate Scientist II Protein Expression Purification amp Characterization

Company name
Pandion Therapeutics

Location
Watertown, MA, United States

Employment Type
Full-Time

Industry
Sciences, Scientist, Biotech, Chemistry

Posted on
Apr 02, 2020

Valid Through
Jul 16, 2020

Apply for this job






Profile

Pandion Therapeutics is an exciting company focused on drug discovery and development in autoimmunity and inflammation. We are currently expanding and seeking a talented Associate Scientist to join Pandion’s Therapeutic Protein Technologies team. The company is located in Watertown.

RESPONSIBILITIES

Maintain EXPI293 and EXPI CHO transient cell lines

Perform expression and purification of antibodies and Fc-fusion proteins.

Perform basic protein characterization assays (SDS-PAGE, Western Blot, UV-Vis spectroscopy, analytical SEC, DLS)

Conduct protein chemical/physical stability, polyreactivity, and self-interaction studies (DSF, ELISA, AC-SINS, CIC, FcRn assay)

Thoroughly document experiments and communicate results across Program Teams

KNOWLEDGE AND SKILL REQUIREMENTS

Basic cell culture skills and sterile technique

Experience transiently expressing protein and stable CHO pool/line generation

Knowledge and skills in basic chromatographic techniques (affinity, IEX, HIC and SEC)

Experience with commercial FPLC and HPLC systems

Intellectual curiosity: willingness to learn

Excellent organizational and time management skills

Ability to thrive in a multi-disciplinary entrepreneurial start-up environment that is highly collaborative, fast-paced, and team-oriented

Effective verbal and written communication skills

EDUCATION AND EXPERIENCE

Bachelor’s or Masters Degree in Analytical Chemistry/Biochemistry/Cell Biology/Molecular Biology or a related discipline with at least 2 years of relevant experience

ABOUT PANDION

Pandion Therapeutics was founded in 2017 with the mission to develop bispecific antibody therapeutics that act at the local site of disease, offering the potential for significantly improved therapeutic options beyond systemic immunosuppressive treatments. We aim to shift the paradigm and create a new generation of drugs with transformative efficacy and improved safety to treat immune-related conditions such as inflammatory bowel disease, type 1 diabetes, and autoimmune liver, kidney and skin diseases. Pandion was recently recognized as a 2018 Fierce 15 Winner.

Pandion Therapeutics is committed to diversity, and proud to be an equal opportunity employer. All qualified candidates will be considered for employment, regardless of race, color, age, ancestry, religion, national origin, gender, gender identity, genetic information, parental or pregnancy status, sexual orientation, citizenship, marital status, disability, or Veteran status.

Company info

Pandion Therapeutics

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