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Protein Scientist - Chemical Biology Cambridge

Company name
Merck & Co., Inc

Cambridge, MA

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The Merck Research Laboratories (MRL) Exploratory Science Center (ESC) Cambridge, a wholly owned subsidiary of Merck and Co., is focused on driving early discovery research. Co-located with Merck’s Cambridge Innovation Hub, the ESC’s disease-area-agnostic research agenda fosters hands-on collaboration between our scientists and external academic and biotech researchers to access and explore the most promising emerging science.

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of an individual like you. To this end, we strive to create a fast-paced, nimble and flexible environment of mutual respect, creativity, invention and teamwork. With access to Merck’s proven global R&D organization, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.

We are seeking an innovative and experienced protein scientist to join the Merck Exploratory Science Center (MESC) in Cambridge, MA.

The successful candidate will become part of a lab-based, creative and fast-paced team that will discover novel biology and invent impactful technologies targeting these areas:

Interaction between the microbiome and human cells/tissue, including the immune system

Host-pathogen interactions in important infectious diseases

Approaches that will impact other key areas of focus within Merck, such as oncology, inflammation, cardiovascular, metabolism, and neuroscience

This is a lab-based position and an excellent opportunity for someone seeking scientific and career growth in a multidisciplinary area of drug discovery.

Your personal growth and career development will contribute to the success of our team.

Responsibilities include and are not limited to the following:

Manage the maintenance and daily operation of a Thermo LC and Q-Exactive HF Orbitrap

Develop and execute nanoflow LC-MS/MS workflows for discovery proteomics focused on i

dentifying and characterizing novel protein-protein and protein-ligand interactions

Investigating potential therapeutic targets by designing and performing biochemical and cellular experiments that will be analyzed using


Characterizing protein bioconjugates to determine labeling ratios and identify sites of conjugation

, such as Drug-to-Antibody Ratio (DAR) Calculations for Antibody-Drug Conjugates (ADCs)

Protein-small molecule binding-site elucidation

Developing novel techniques and solutions to challenging scientific questions

The candidate will be part of a cross-functional team contributing to the strategic direction of research programs across multiple therapeutic modalities

Act as a leader from the bench, driving experimentation design and execution

Provide scientific mentoring and technical training of team members as appropriate

Ensure all laboratory safety protocols are followed



Required: M.S. in Biochemistry, Protein Sciences, Chemical Biology, Biomedical Sciences or related discipline

Required Experience:

Minimum of (5) years Academic or Pharmaceutical industry experience

Independent experimental design and execution of experiments

Rigorous scientific thinking and effective written and oral communication skills

Broad technical experience using LC/MSMS proteomics

Familiar with protein sample preparation, various protein labelling technologies, QC analysis, data processing, statistical analysis tools and protein identification

Experience using Thermo Orbitrap instrument(s)

Preferred Experience:

Demonstrated critical thinking and trouble-shooting ability when handling challenging proteins such as aggregated protein, multicomponent complex, or membrane proteins

Targeted and

quantitative bottom-up proteomics experience

Experience designing and performing biochemical and cellular experiments

Q Exactive LC-MS/MS experience

Experience with activity and affinity-based chemoproteomics

Experience with post-translation modifications (eg. Glycosylation, lipidation, etc)

Passionate about biomedical research and drug discovery

Our employees are the key to our company’s success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Our Company’s benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives. If you need an accommodation for the application process please email us at [email protected]

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for all of us.


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Company info

Merck & Co., Inc
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Company Profile
Merck has a long and rich history of working to improve people's health and well-being. Through the years, our researchers have helped to find new ways to treat and prevent illness - from the discovery of vitamin B1, to the first measles vaccine, to cold remedies and antacids, to the first statins to treat high cholesterol. Our scientists also have helped develop many products to improve animal health, including vaccines and antibiotics. /images/merck-history-timeline-screen.jpgWhile we are proud of our past, we are enthusiastic about the future of this new company and we are excited to help create a healthier, brighter future for people around the world.

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