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Bioinformatics Scientist II

Company name
Cielo, Inc.

Philadelphia, PA

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Job Description
Req ID: 12222\r\rShift: Days\r\rEmployment Status: AF - Active - Regular - Full Time \r\r\rJob Summary\r\r
\rThe Children’s Hospital of Philadelphia Research Institute is an interdisciplinary institution dedicated to conducting basic, clinical and translational research on conditions and diseases that affect children, and is part of The Children's Hospital of Philadelphia and University of Pennsylvania research community.\r\r\r\rThe Bioinformatics Scientist position is in the laboratory of Dr. Dimitri Monos, Director of the Immunogenetics Laboratory in the Division of Genomic Diagnostics of the Department of Pathology and Laboratory Medicine.\r\r\r \rThe lab’s research focuses on the role of Histocompatibility (HLA) molecules and of the Major Histocompatibility Complex (MHC) in autoimmunity and transplantation.  We are interested in the detailed characterization of the MHC by high throughput DNA sequencing technologies and the identification of polymorphisms important for many HLA-associated diseases and rejection processes in transplantation. The lab is supported by institutional, NIH and other Foundations’ grants.\r\r\r\rTo learn more about the CHOP Research Institute, Dr. Dimitri Monos and the research programs visit:\r\rInterested individuals should send a cover letter, CV and must also complete a profile on our website at  References and/or letters of recommendation will be requested.\r\rRequired Education and Experience\r\r
\rEDUCATION, SKILLS AND ABILITIES:\r\r\r\ro Ph.D. in bioinformatics, computational biology, computer science, mathematics, engineering or related discipline; or MS with at least three years of related experience\ro Experience with experimental design, analysis, and interpretation of large multivariate datasets generated from a variety of platforms, such as SNP microarray, expression microarray, NGS, and single molecule sequencing platforms (PacBIO and Oxford Nanopore MinION)\ro Demonstrated skills utilizing bioinformatics algorithms, tools and resources, e.g. sequence retrieval, alignment and clustering techniques, expression profiling and protein related analysis, using major databases and data standards in the field.\ro Ability to design, develop, validate and maintain computational tools and algorithms for the analysis and interpretation of NGS data\ro Experience working with UNIX/LINUX in a high performance computing environment\ro Fluency in C /JAVA, PERL/Python, R/Matlab, or other programming languages\ro Strong working knowledge or training in advanced biomedical research (Background in Immunology, Histocompatibility, Immunogenetics, and/or HLA experience preferred)\ro Experience with manuscript and grant preparation is preferred\ro Ability to work collaboratively in a dynamic research environment\ro Effective critical thinking and problem solving skills\ro Excellent interpersonal skills to interact and communicate with both clinical lab technical staff and research staff\ro Excellent writing, communication, and analytical skills\ro Ability to work independently with minimal guidance while consistently exercising good judgment\ro Ability to learn new technologies quickly\ro Ability to work efficiently on multiple projects\r\rPreferred Education, Experience & Cert/Lic\r\r
\rFamiliarity with next-generation sequencing and analysis is preferred.  The successful applicant will become part of a highly interactive team that uses molecular biology, statistical genetics and bioinformatics to study the intricacies of the MHC. Postdoc/scientist will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. The postdoc/scientist will also be expected to acquire technical, lab management, and manuscript/grant writing skills and will also participate in seminars, lectures, poster sessions and presentations at national meetings.\r\r\rThe acquired experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background and develop new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group.\r\r\r\rSalary will be based on experience and skills. Future academic appointment may be considered.\rAll CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.\r\rChildren's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products or nicotine in any form and a negative nicotine screen (the latter occurs after a job offer).\r\rChildren's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.\r\rVEVRAA Federal Contractor/Seeking priority referrals for protected veterans.  Please contact our hiring official with any referrals or questions.\r\rCHOP Careers Contact \r\rTalent Acquisition\r\r2716 South Street, 6th Floor\r\rPhiladelphia, PA 19146 \r\rPhone: 866-820-9288 \r\\r\r\r\r

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Cielo, Inc.

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