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Associate Principal Scientist: Protein Engineering Assay Development

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Rahway, NJ

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Requisition ID: CHE005838Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified itsu00a0legacy for over a century. Mercku2019s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.Merck is on a quest for cures and is committed to being the worldu2019s premier, most research-intensive biopharmaceutical company. Today, weu2019re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Mercku2019s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.u00a0Highly motivated scientists are being sought to join the Protein Engineering group in the Department of Biochemical Engineering & Structure.u00a0 The group works out of the Rahway, NJ site and multiple opportunities are available.u00a0 u00a0Successful candidates will join a group of innovative scientists with broad deliverables ranging from evolved enzymes for biocatalytic implementation in drug manufacturing routes to the delivery of optimized protein scaffolds to enable discovery.u00a0 These are scientific positions that require critical thinking, flexibility, multitasking, and the ability to bring in new technologies to enable rapid design, generation, and testing of engineered proteins.u00a0u00a0QualificationsEducation:u00a0M.S with a minimum of 7 years experience OR Ph.D. with a minimum of 4u00a0years experience in Biochemistry or related fieldu00a0Required:u00a0Experience developing and running high-throughput screening assays with automated liquid handlingExperience with multiple types of biochemical assays (FACS, ELISA, HTRF, SPR, Fluorescence, etc)u00a0Experience with enzyme kinetics (Vmax, Km, product inhibition, substrate preference)u00a0u00a0Knowledge of statistics (e.g. average, standard deviation coefficient of variation, outlier detection, histograms, population analysis)Experience leading multi-disciplinary teams to deliver on goalsStrong written and oral communication skillsu00a0Strong leadership and organizational skillsPreferred:Experience with molecular biology and protein expression technologyExperience characterizing the biophysical properties of proteins via SDS-PAGE, Western Blot, spectrophotometric assays, and SEC-HPLCKnowledge of biocatalysis and directed evolution approaches to generate improved proteinsExperience using analytical instrumentation such as UPLC, HPLC, LC-MS, and GCu00a0u00a0Good grasp of organic chemical principles and comfort with the use of organic chemicalsDemonstrated ability to generate novel ideas and conceptsu00a0Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and weu2019re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, weu2019re inventing for life.u00a0u00a0If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to ****. u00a0u00a0Search Firm Representatives Please Read Carefully:u00a0Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity.u00a0 Please, no phone calls or emails.u00a0 All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck.u00a0 No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.u00a0For more information about personal rights under Equal Employment Opportunity, visit:u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0EEOC Posteru00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0EEOC GINA Supplementu00a0Job: ChemistryOther Locations: Employee Status: RegularTravel: Number of Openings: 1Shift (if applicable): Hazardous Materials: Depends on program being supportedCompany Trade Name: Merck,employmentType:[,OTHER],title:Associate Principal Scientist: Protein Engineering Assay Development,url:****Jersey,addressCountry:United States,postalCode:07065}},hiringOrganization:{@type:Organization,name:Merck,logo:****{@context:****Principal Scientist: Protein Engineering Assay Development}}]}

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