Research Scientist - Biomarker / Cell BiologyThe Company: A major global biopharmaceutical corporation focused on the discovery, the development, and the commercialization of products for the treatment of cancer and other severe, immune, inflammatory conditionsThe Role:Research scientist with proven success at the bench. Possesses a strong understanding of science behind ongoing experiments: the rationale, purpose and appropriate analytical methods. The position holder works virtually independently toward defined objectives conducting several complex experiments, some in parallel, and offering insight into future experiments. The scientist displays initiative in learning new techniques and research approaches and communicates results to supervisors and teams.Position: Research Scientist - Biomarker / Cell BiologyLocation: Summit, NJDuration: 1-year contract with extendable opportunities.Required Skillset/Background:* A MS or BS degree in a field of cell biology, biochemistry or molecular biology* 5-7 years hands-on research experience.* Experience in drug discovery, oncogenic and immune cell signal transduction and translational medicine is a plus. * Basic knowledge of oncogenic/immunological signaling pathways and actively follows the scientific literature.* Excellent communication skills to effectively convey scientific concepts and data with internal working groups/project teams and external academic and industrial organizations.* Team player, excellent written and verbal communication skills *** Experience with primary cell culture, co-cultures, flow cytometry and inducible gene silencing are a plus.***Day - to - Day responsibilities:1. Assay development to support biomarker strategies for clinical trials 2. Develop in-vitro assays for evaluating mechanisms of drug resistance, drug differentiation and pharmacodynamic marker identification (develop resistant cell lines, make stable and conditional knock-downs and knock-ins, cellular trafficking studies) 3. Study the intracellular signaling networks and feedback mechanisms within pertinent cell types to assess mechanism of action and rationalize drug combination strategy. 4. Interface with bioinformaticians to analyze genomics data for understanding pathways of resistance and differentiation of drugs in development 5. Participate in translational team meetings to present data and provide interpretation 6. Analyze, interpret, and present experimental results. 7. Ensures that the Translational Development Department maintains current awareness in area of expertise, enhances the scientific credibility of the client through contributions to the scientific literature (publications/presentations), through extramural activities and scientifically related interactions with academics 8. Contributes to bringing new technologies in-house 9. Assumes responsibility for writing non-clinical pharmacology study reports, invention disclosures, and contribute to the writing of investigator brochures, IND applications, regulatory annual reports, and other regulatory documents when appropriate.Sthree US is acting as an Employment Business in relation to this vacancy.
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