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Postdoctoral Research Fellow Cancer Immunology Genentech Research

San Francisco, CA

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Genentech: Postdoctoral Research Fellow, Cancer Immunology, Genentech Research
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Postdoctoral Research Fellow, Cancer Immunology, Genentech Research
South San Francisco
California, United States of America
Job ID: 201805-106477
The Position
We are seeking an independent and motivated researcher for a Postdoctoral Fellowship in the lab of Jane Grogan in the Department of Cancer Immunology to the role of T cells, innate lymphocytes and myeloid cells in cancer. The successful candidate will join a research team that combines genetic, cellular, molecular and imaging tools to discover and elucidate novel pathways that regulate tumorogenesis in vivo. Studies will include detailed analysis of signaling pathways that predominate in tumor primary and metastatic microenvironments.
Selected publications from the Grogan lab:
Manieri N, Chiang EY, Grogan JL. (2017)
TIGIT: a Key Inhibitor of the Cancer Immunity Cycle. Trends in Immunology
Jan;38(1):20-28. doi: 10.1016/ Johnston RJ, Comps-Agrar L, Hackney J, Yu X, Huseni M, Yang Y, Park S, Javinal V, Chiu H, Irving B, Eaton DE, Grogan
JL. (2014) The immunoreceptor TIGIT regulates anti-tumor and anti-viral CD8 T cell effector function. Cancer Cell
, 26:923-37 Yu X, Pappu R, Ramirez-Carrozzi V, Ota N, Caplazi P, Zhang J, Yan D, Xu M, Lee LP, Grogan JL
. (2013)
Mucosal Immunology
, Nov 13. doi: 10.1038/mi.2013.92 Chiang EY, Li T, Jeet S, Peng I, Zhang J, Lee WP, DeVoss J, Caplazi P, Chen J, Warming S, Hackos DH, Mukund S, Koth CM, Grogan JL
. (2017)
Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell function. Nature Communications
, Mar 1;8:14644. doi: 10.1038/ncomms14644. Stengel KF, Harden-Bowles K, Yu X, Rouge L, Yin J, Comps-Agrar L, Wiesmann C, Bazan JF, Eaton DL, Grogan JL
. (2012)
Proceedings National Academy of Sciences USA
, 109, 5399-5404 Chiang EY, Kolumam GA, Yu X, Francesco M, Ivelja S, Peng I, Gribling P, Shu J, Lee WP, Refino CJ, Balazs M, Paler-Martinez A, Nguyen A, Young J, Barck KH, Carano RAD, Ferrando R, Diehl L, Chatterjea D, Grogan JL. (2009)
Targeted depletion of lymphotoxin-alpha-expressing Th1 and Th17 cells inhibits autoimmune disease. Nature Medicine
, 15:766-773 Yu X, Harden K, Gonzalez L, Francesco M, Chiang E, Irving B, Tom I, Ivelja S, Refino CJ, Clark H, Eaton D and Grogan JL.
( 2009
) TIGIT is a T cell specific IgV receptor that negatively modulates T cell activation by inducing mature immunoregulatory dendritic cells. Nature Immunology
, 10, 48-57
Who You Are
A PhD or MD/PhD, a strong background in immunology, molecular biology and cell biology and a strong track record of prior accomplishments as evidenced by at? least one first-author paper published or accepted in a top tier journal is required. Qualified candidates must also demonstrate outstanding communication skills, have a strong passion and commitment?to science and work well within a group. Knowledge of murine models of autoimmune and tumor models is desirable but not essential.
For more information about Jane Grogan's lab, please visit ****For more information about the postdoc program, please visit
****Who We Are
A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.
The next step is yours. To apply today, click on the Apply online button.
Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our .
At Genentech, we share salary ranges with applicants during the recruiting process, if requested. Third party salary estimates may not be accurate or up-to-date.
Job Facts
Job Function
South San Francisco
California, United States of America
Full time
Job type
Temporary (Fixed Term)
Biotechnology / Science

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